Article
Co-presence of a point mutation and a deletion of exon 3 in the glycophorin C gene and concomitant production of a Gerbich-related antibody.
Transfusion - 1 Oct 1997
King M J, Kosanke J, Reid M E, Poole J, Banks J, Hemming N J, Smythe J, Martin P G
Abstract excerpt
BACKGROUND: Antigens of the human blood group system Gerbich (Ge) are located on sialoglycoproteins glycophorin C (GPC) and glycophorin D (GPD). CASE REPORT: The Ge+ proposita (RW) produced an alloanti-Ge after receiving 2 units of red cells (RBCs) during surgery. Further studies were carried out...
Topics
- Animals
- Antibodies, Monoclonal
- Blood Group Incompatibility
- Blotting, Western
- DNA, Complementary
- Exons
- Female
- Gene Deletion
- Glycophorins
- Humans
- Isoantibodies
- Male
- Mice
- Phenotype
- Point Mutation
- Polymerase Chain Reaction
- Sequence Analysis