Article
First example of hemolytic disease of the newborn caused by anti-Or and confirmation of the molecular basis of Or.
Vox sanguinis - 1 Jan 2000
Reid M E, Sausais L, Oyen R, Storry J R, Shukla H, Hsu T, Lim S M
Abstract excerpt
BACKGROUND AND OBJECTIVES: The rare MNS antigen Or (MNS31) is sensitive to ficin, papain and sialidase, but partially resistant to trypsin (0.05%); the effect of alpha-chymotrypsin is not known. A point mutation, 204C --> T in exon 3 of GYPA, is associated with the Or+ phenotype. We report here the first case of hemolytic disease of the newborn (HDN) caused by anti-Or, and expand the information on the nature of...
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