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Article

The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes.

Mechanisms of development - 1 Mar 2003

Nolte Christof, Amores Angel, Nagy Kovács Erzsébet, Postlethwait John, Featherstone Mark

Abstract excerpt

The zebrafish hoxd4a locus was compared to its murine ortholog, Hoxd4. The sequence of regulatory elements, including a DR5 type retinoic acid response element (RARE) required for Hoxd4 neural enhancer activity, are highly conserved. Additionally, zebrafish and mouse neural enhancers function identically in transgenic mouse embryos. We tested whether sequence conservation reflects functional importance by...

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PMID: 12591602
DOI: 10.1016/s0925-4773(02)00442-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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