Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells.

Toxicology - 1 Sept 2017

Slotkin Theodore A, Skavicus Samantha, Stapleton Heather M, Seidler Frederic J

Abstract excerpt

In addition to their activity as endocrine disruptors, brominated and organophosphate flame retardants are suspected to be developmental neurotoxicants, although identifying their specific mechanisms for that activity has been elusive. In the current study, we evaluated the effects of several flame retardants on neurodifferentiation using two in vitro models that assess distinct "decision nodes" in neural cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Embryonic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neural Stem Cells

Share to Neurogenesis

Share to Neuroglia

Share to Neurotoxicity Syndromes

Share to Organophosphorus Compounds

Share to PC12 Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 28851516
DOI: 10.1016/j.tox.2017.08.009
PMCID: PMC5633518

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells.PMID 28851516Read ↗

BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.Semantic proximity Read ↗

Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.Semantic proximity Read ↗

Chlorpyrifos Affects Phenotypic Outcomes in a Model of Mammalian Neurodevelopment: Critical Stages Targeting Differentiation in PC12 CellsSemantic proximity Read ↗

Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.Semantic proximity Read ↗

TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPsSemantic proximity Read ↗

BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of actionSemantic proximity Read ↗

Nuclear hormone receptors control fundamental processes of human fetal neurodevelopment: Basis for endocrine disruption assessmentSemantic proximity Read ↗

Differential Neurodevelopmental Disruption by Bisphenol A (BPA) and Valproic Acid (VPA) in Human Forebrain OrganoidsSemantic proximity Read ↗

Benzo[a]pyrene-induced AHR activation in human ESCs primes premature neurogenesis in brain organoidsSemantic proximity Read ↗

Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicitySemantic proximity Read ↗

Neurotoxicity screening in a multipotent neural stem cell line established from the mouse brain.Semantic proximity Read ↗

Compound selection for in vitro modeling of developmental neurotoxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.