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Article

Considerations for the Use of SH-SY5Y Neuroblastoma Cells in Neurobiology.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Kovalevich Jane, Santerre Maryline, Langford Dianne

Abstract excerpt

The use of primary mammalian neurons derived from embryonic central nervous system tissue is limited by the fact that once terminally differentiated into mature neurons, the cells can no longer be propagated. Transformed neuronal-like cell lines can be used in vitro to overcome this limitation. However, several caveats exist when utilizing cells derived from malignant tumors. In this context, the popular SH-SY5Y...

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PMID: 34033074
DOI: 10.1007/978-1-0716-1437-2_2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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