Article
Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy.
The American journal of pathology - 1 Nov 1998
Arbustini E, Diegoli M, Fasani R, Grasso M, Morbini P, Banchieri N, Bellini O, Dal Bello B, Pilotto A, Magrini G, Campana C, Fortina P, Gavazzi A, Narula J, Viganò M
Abstract excerpt
Mitochondrial (mt)DNA defects, both deletions and tRNA point mutations, have been associated with cardiomyopathies. The aim of the study was to determine the prevalence of pathological mtDNA mutations and to assess associated defects of mitochondrial enzyme activity in dilated cardiomyopathy (DCM...
Topics
- Adolescent
- Adult
- Biopsy
- Cardiomyopathy, Dilated
- DNA, Mitochondrial
- Female
- Humans
- Male
- Middle Aged
- Mitochondria, Heart
- Mutation
- Mutation, Missense
- NADH Dehydrogenase
- Polymerase Chain Reaction