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Article

Mutations in the cardiac mitochondrial DNA control region associated with cardiomyopathy and aging.

Journal of cardiac failure - 1 Apr 2002

Marín-García José, Zoubenko Oleg, Goldenthal Michael J

Abstract excerpt

BACKGROUND: An age-dependent accumulation of point mutations in the noncoding control region of human mitochondrial D-loop has been found in cultured fibroblasts and muscle cells. Damage in mitochondrial DNA (mtDNA) coding genes and decreased bioenergetic generation have also been found in human cardiac tissues with aging and in cardiac disease. METHODS AND RESULTS: We analyzed cardiac mtDNA for the incidence and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12016633
DOI: 10.1054/jcaf.2002.32501

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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