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Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA) structural conservation and the detection of a nucleolar form

1 May 1990

Abstract excerpt

The proliferating cell nuclear antigen, PCNA, has recently been identified as the polymerase delta accessory protein. PCNA is essential for cellular DNA synthesis and is also required for the in vitro replication of simian virus 40 (SV40) DNA where it acts to coordinate leading and lagging strand synthesis at the replication fork. The cDNA for rat PCNA was cloned into a series of bacterial expression vectors and...

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PMID: 1695635
DOI: 10.1242/jcs.96.1.121

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