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Article

Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2.

Molecular and cellular biology - 1 Nov 1997

Capobianco A J, Zagouras P, Blaumueller C M, Artavanis-Tsakonas S, Bishop J M

Abstract excerpt

The Notch genes of Drosophila melanogaster and vertebrates encode transmembrane receptors that help determine cell fate during development. Although ligands for Notch proteins have been identified, the signaling cascade downstream of the receptors remains poorly understood. In human acute lymphoblastic T-cell leukemia, a chromosomal translocation damages the NOTCH1 gene. The damage apparently gives rise to a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9343387
DOI: 10.1128/MCB.17.11.6265
PMCID: PMC232477

Genes

NOTCH1
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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