Article
Sensitive bioaffinity assays with individual microparticles and time-resolved fluorometry.
Clinical chemistry - 1 Oct 1997
Lövgren T, Heinonen P, Lehtinen P, Hakala H, Heinola J, Harju R, Takalo H, Mukkala V M, Schmid R, Lönnberg H, Pettersson K, Iitiä A
Abstract excerpt
Future immunoassays and nucleic acid hybridization assays will be performed in miniaturized formats that utilize microchips or microparticles. This will require a sensitive detection technology that allows spatial resolution. By using fluorescent europium chelates and time-resolved microfluorometry, one can detect 11,000 europium molecules on individual microparticles. In a miniaturized noncompetitive immunoassay...
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