[MELAS (mitochondrial myopathy, encephalopathy lactic acidosis, and stroke-like episodes): clinical features and mitochondrial DNA mutations].

Article

[MELAS (mitochondrial myopathy, encephalopathy lactic acidosis, and stroke-like episodes): clinical features and mitochondrial DNA mutations].

Nihon rinsho. Japanese journal of clinical medicine - 1 Sept 1993

Goto Y

Abstract excerpt

MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) is one of the clinically-defined mitochondrial diseases, characterized by early onset and stroke-like symptoms. A point mutation at nucleotide pair 3243 within the tRNA-Leu (UUR) gene is found in 80% of MELA...

Topics

Adolescent
Base Sequence
Child
Child, Preschool
DNA, Mitochondrial
Humans
Infant
MELAS Syndrome
Molecular Sequence Data
Mutation
Phenotype
RNA, Transfer, Leu
Transcription, Genetic

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