[Effect of the amide of 1-adamantanecarboxylic acid (AACA) and its combination with ribavirin on the course of experimental infection, caused by the sindbis virus in tissue culture and in mouse brain. Possible isolation of the virus mutant resistant to ribavirin and to a combination of the inhibitors].

Abstract excerpt

It was shown advisable to use ribavirin (a weak inhibitor of Sindbis virus reproduction) in combination with ACAA. The effect observed was of marked synergistic nature. Subcultures of the susceptible strain in the presence of ribavirin/ ACAA did not lead to the development of resistance to ACAA, ribavirin or their combination. The ACAA resistant strain preserved its susceptibility to ribavirin after serial...

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