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Article

Antibacterial activity of a new tetracyclic quinolone, No. 5290, against norfloxacin- and ciprofloxacin-resistant strains of Staphylococcus aureus.

Chemical & pharmaceutical bulletin - 1 Oct 1991

Kotera Y, Inoue Y, Ohashi M, Ito K, Tsukamoto G

Abstract excerpt

The antibacterial activity of a new tetracyclic quinolone, No. 5290, against 25 strains of Staphylococcus aureus clinically isolated in Japan in 1988-1989 was determined. The minimum inhibitory concentrations (MICs) of No. 5290 against both quinolone-susceptible (MIC: norfloxacin less than or equal to 6.25 micrograms/ml, ciprofloxacin less than or equal to 1.56 micrograms/ml) and 4 out of 5 norfloxacin- and...

Topics

Anti-Infective Agents
Chromatography, High Pressure Liquid
Ciprofloxacin
Drug Resistance, Microbial
Fluoroquinolones
Mutation
Norfloxacin
Piperazines
Quinolones
Staphylococcus aureus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Thiazoles

Source

Identifiers

PMID: 1666861
DOI: 10.1248/cpb.39.2644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1666861-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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