Article
Mechanism of suppression of piperacillin resistance in enterobacteria by tazobactam.
Antimicrobial agents and chemotherapy - 1 Oct 1997
Kadima T A, Weiner J H
Abstract excerpt
Resistance to piperacillin in several isolates of Citrobacter freundii and Enterobacter cloacae was investigated and confirmed to occur at a frequency of 10(-7) to 10(-6). Development of resistance to piperacillin was significantly suppressed by tazobactam but not by clavulanic acid. To elucidate the mechanism by which resistance suppression occurs, the effect of piperacillin plus tazobactam on the induction of...
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