Article
Effects of tazobactam on the frequency of the emergence of resistant strains from Enterobacter cloacae, Citrobacter freundii, and Proteus vulgaris (beta-lactamase derepressed mutants).
The Journal of antibiotics - 1 Sept 1995
Higashitani F, Nishida K, Hyodo A, Inoue M
Abstract excerpt
When Enterobacter cloacae, Citrobacter freundii, and Proteus vulgaris were treated with piperacillin (PIPC) in combination with tazobactam (TAZ), the in vitro frequency of emergence of resistant strains (beta-lactamase producing mutants) was lower than with PIPC or ceftazidime (CAZ) treated bacte...
Topics
- Animals
- Citrobacter freundii
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Enterobacter cloacae
- Enterobacteriaceae Infections
- Enzyme Inhibitors
- Male
- Mice
- Microbial Sensitivity Tests
- Mutation
- Penicillanic Acid
- Piperacillin
- Proteus vulgaris
- Tazobactam
- beta-Lactamase Inhibitors
- beta-Lactamases