Article
A novel deletion of the MEN1 gene in a large family of multiple endocrine neoplasia type 1 (MEN1) with aggressive phenotype.
Clinical endocrinology - 1 Dec 2011
Raef Hussein, Zou Minjing, Baitei Essa Y, Al-Rijjal Roua A, Kaya Namik, Al-Hamed Mohamed, Monies Dorota, Abu-Dheim Nada N, Al-Hindi Hindi, Al-Ghamdi Mohammed H, Meyer Brian F, Shi Yufei
Abstract excerpt
CONTEXT: The MEN1 syndrome is associated with parathyroid, pancreatic and pituitary tumours and is caused by mutations in the MEN1 gene. In general, there is no genotype-phenotype correlation. OBJECTIVES: To characterize a large family with MEN1 with aggressive tumour behaviour: malignant pancreatic endocrine tumours were present in five affected subjects and were the presenting features in three subjects....
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