Germline and somatic mosaicism in a family with multiple endocrine neoplasia type 1 (MEN1) syndrome

Abstract excerpt

Context Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease caused by mutations in the tumor suppressor gene MEN1 and can be diagnosed based on clinical, familial and/or genetic criteria. We present a family in which we found both germline and somatic mosaicism for MEN1. Family description In our proband, we diagnosed MEN1. The mutation was not detected in her parents (DNA extracted from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Lung Cancer Research Studies
• Share to Microtubule and mitosis dynamics
• Share to Neuroendocrine Tumor Research Advances