Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.

Journal of molecular biology - 26 Sept 1997

Alvarez A, Opazo C, Alarcón R, Garrido J, Inestrosa N C

Abstract excerpt

Acetylcholinesterase (AChE), an enzyme involved in the hydrolysis of the neurotransmitter acetylcholine, consistently colocalizes with the amyloid deposits characteristic of Alzheimer's disease and may contribute to the generation of amyloid proteins and/or physically affect fibril assembly. In o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholinesterase
Share to Amino Acid Sequence
Share to Amyloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid beta-Peptides

Share to Molecular Sequence Data

Share to Mutation

Share to Peptide Fragments

Share to Protein Binding

Source

Identifiers

PMID: 9325095
DOI: 10.1006/jmbi.1997.1245

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9325095-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.PMID 9325095Read ↗

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.Semantic proximity Read ↗

Acetylcholine Hydrolytic Activity of Fibrillated β-Amyloid (1-40) PeptideSemantic proximity Read ↗

In vivo localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer's diseaseSemantic proximity Read ↗

Acetylcholinesterase modulates presenilin-1 levels and γ-secretase activity.Semantic proximity Read ↗

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of AcetylcholinesteraseSemantic proximity Read ↗

Structural roles of acetylcholinesterase variants in biology and pathology.Semantic proximity Read ↗

Beta-amyloid and cholinergic neurons.Semantic proximity Read ↗

The cholinergic neuronal phenotype in Alzheimer's disease.Semantic proximity Read ↗

The Abeta1-42M35C mutated amyloid peptide Abeta1-42 and the 25-35 fragment fail to mimic the subtype-specificity of actions on recombinant human nicotinic acetylcholine receptors (alpha7, alpha4beta2, alpha3beta4).Semantic proximity Read ↗

Metal loading capacity of Abeta N-terminus: a combined potentiometric and spectroscopic study of zinc(II) complexes with Abeta(1-16), its short or mutated peptide fragments and its polyethylene glycol-ylated analogue.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.