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Article

Beta-amyloid and cholinergic neurons.

Neurochemical research - 1 Apr 2003

Dolezal Vladimír, Kasparová Jana

Abstract excerpt

It is generally accepted that the crucial events in the pathogeny of Alzheimer's disease (AD) are the increased accumulation of amyloidogenic peptides derived from amyloid precursor protein and the harmful actions of these peptides on neurons, which bring about neurodegeneration. The enhanced beta-amyloid accumulation is known to be caused by mutations of specific genes in patients who suffer from the familial...

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PMID: 12675138
DOI: 10.1023/a:1022865121743

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