Article
[Dynamic monitoring of minimal residual disease in acute lymphoid leukemia].
Zhongguo shi yan xue ye xue za zhi - 1 Dec 2011
Shan Shi-Long, Xing Hai-Yan, Tian Zheng, Tang Ke-Jing, Rao Qing, Wang Min, Wang Jian-Xiang
Abstract excerpt
The aim of this study was to establish a method for quantitative detection of immunoglobulin heavy chain (IgH) gene rearrangements and to explore its clinical application in monitoring minimal residual disease (MRD) of acute lymphoid leukemia (ALL). Clonal IgH gene rearrangements in 51 patients with ALL at diagnosis were identified by multiplex PCR assay. PCR products were sequenced and pairwise in IMGT data...
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