Article
CYP1A2 and CYP2D6 Gene Polymorphisms in Schizophrenic Patients with Neuroleptic Drug-Induced Side Effects.
Bulletin of experimental biology and medicine - 1 Mar 2016
Ivanova S A, Filipenko M L, Vyalova N M, Voronina E N, Pozhidaev I V, Osmanova D Z, Ivanov M V, Fedorenko O Yu, Semke A V, Bokhan N A
Abstract excerpt
Polymorphic variants of CYP1A2 and CYP2D6 genes of the cytochrome P450 system were studied in patients with schizophrenia with drug-induced motor disorders and hyperprolactinemia against the background of long-term neuroleptic therapy. We revealed an association of polymorphic variant C-163A CYP1A2*1F of CYP1A2 gene with tardive dyskinesia and association of polymorphic variant 1846G>A CY2D6*4 and genotype A/A of...
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