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Article

Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines

10 Oct 1997

Abstract excerpt

Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood...

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Identifiers

PMID: 9323208
DOI: 10.1126/science.278.5336.290

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