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HHV8-encoded vMIP-I Selectively Engages Chemokine Receptor CCR8

1 Jul 1999

Abstract excerpt

Uncertainty regarding viral chemokine function is mirrored by an incomplete knowledge of host chemokine receptor usage by the virally encoded proteins. One such molecule is vMIP-I, a C-C type chemokine of undefined function and binding specificity, encoded by the Kaposi's sarcoma herpesvirus HHV-8. We report here that vMIP-I binds to and induces cytosolic [Ca(2+)] signals in human T cells selectively through...

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PMID: 10419462
DOI: 10.1074/jbc.274.31.21569

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