Article
HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2
17 Aug 2012
Abstract excerpt
Vascular diseases supported by aberrant angiogenesis have increased incidence in HIV-1-infected patients. Several data suggest that endothelium dysfunction relies on action of HIV-1 proteins rather than on a direct effect of the virus itself. The HIV-1 matrix protein p17 is known to deregulate the biological activity of different immune cells. Recently, p17 was found to mimic IL-8 chemokine activity by binding to...
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