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Article

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

6 Dec 1996

Abstract excerpt

Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar...

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PMID: 8939871
DOI: 10.1126/science.274.5293.1739

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