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Article

Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product.

The American journal of physiology - 1 Sept 1997

Pajak L, Jin F, Xiao G H, Soonpaa M H, Field L J, Yeung R S

Abstract excerpt

Tuberous sclerosis complex (TSC) is characterized by the appearance of nonmalignant tumors that affect a wide spectrum of organs, including the heart. TSC disease-causing genes have been identified on chromosomes 9 (TSC1) and 16 (TSC2). This study examined the impact of the TSC2 gene product on cardiomyocyte proliferation and terminal differentiation. We took advantage of the observation that Eker rats carry a...

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Source

Identifiers

PMID: 9321857
DOI: 10.1152/ajpheart.1997.273.3.H1619

Genes

TSC2
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sustained cardiomyocyte DNA synthesis in whole embryo cultures lacking the TSC2 gene product.PMID 9321857Read ↗

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