Article
Erythropoietin-driven proliferation of cells with mutations in the tumor suppressor gene TSC2.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2011
Ikeda Yoshihiko, Taveira-DaSilva Angelo M, Pacheco-Rodriguez Gustavo, Steagall Wendy K, El-Chemaly Souheil, Gochuico Bernadette R, May Rose M, Hathaway Olanda M, Li Shaowei, Wang Ji-an, Darling Thomas N, Stylianou Mario, Moss Joel
Abstract excerpt
Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction, resulting from proliferation of smooth-muscle-like cells, which have mutations in the tumor suppressor genes TSC1 or TSC2. Among 277 LAM patients, severe disease was associated with hypoxia and elevated red blood cell indexes that accompanied reduced pulmonary function. Because high red cell indexes could result from hypoxemia-induced...
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