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Article

DEAF-1 regulates immunity gene expression in Drosophila.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2008

Reed Darien E, Huang Xinhua M, Wohlschlegel James A, Levine Michael S, Senger Kate

Abstract excerpt

Immunity genes are activated in the Drosophila fat body by Rel and GATA transcription factors. Here, we present evidence that an additional regulatory factor, deformed epidermal autoregulatory factor-1 (DEAF-1), also contributes to the immune response and is specifically important for the induction of two genes encoding antimicrobial peptides, Metchnikowin (Mtk) and Drosomycin (Drs). The systematic mutagenesis of...

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Identifiers

PMID: 18550807
DOI: 10.1073/pnas.0802921105
PMCID: PMC2448840

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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