Oxidative DNA Damage Repair and <i>parp 1</i> and <i>parp 2</i> Expression in Epstein-Barr Virus-Immortalized B Lymphocyte Cells from Young Subjects, Old Subjects, and Centenarians

Abstract excerpt

Oxidative DNA damage has been implicated in the aging process and in some of its features such as telomere shortening and replicative senescence. Poly(ADP-ribosyl)ation is involved in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, and cell death pathways. We decided to examine the behavior of poly(ADP-ribosyl)ation in centenarians, i.e.,...

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