Article
Differential allelic expression of PrP mRNA in carriers of the E200K mutation.
Neurology - 1 Sept 1997
Rosenmann H, Halimi M, Kahana I, Biran I, Gabizon R
Abstract excerpt
Creutzfeldt-Jakob disease (CJD) linked to the E200K mutation of the prion protein (PrP) gene presents with a wide range of age at disease onset. Since most patients are heterozygous for the mutation, we tested whether differential expression of mutant versus wild-type (wt) PrP may affect the age at disease onset in carriers of the mutation. We measured wt and mutant PrP protein and mRNA in Epstein-Barr virus...
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