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Article

Elevated PrPC expression predisposes to increased HSV-1 pathogenicity.

Antiviral chemistry & chemotherapy - 1 Jan 2006

Thackray Alana M, Bujdoso Raymond

Abstract excerpt

PrPC is a ubiquitously expressed glycophos-phatidylinositol-linked cell-surface glycoprotein found primarily in neural tissue. Although its normal function has not been established, there is evidence suggesting that PrPC is involved in cell signalling and cellular homeostasis. This suggests that variation in neuronal expression levels of this protein contributes towards pathogenicity induced by neurotropic...

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PMID: 16542005
DOI: 10.1177/095632020601700106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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