Article
Correction of Fas (CD95) deficiency by haploidentical bone marrow transplantation.
European journal of immunology - 1 Aug 1997
Benkerrou M, Le Deist F, de Villartay J P, Caillat-Zucman S, Rieux-Laucat F, Jabado N, Cavazzana-Calvo M, Fischer A
Abstract excerpt
Recently, an inherited syndrome characterized by nonmalignant lymphoproliferation with autoimmune manifestations, caused by mutations of the Fas (CD95) receptor gene has been described. Because of disease severity, i.e. unremitting lymphoproliferation in a child with complete Fas deficiency, a haploidentical bone marrow transplantation (BMT) was performed despite the known resistance of Fas-deficient lpr mice to...
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