Article
Fate and expression of the deleted mitochondrial DNA differ between human heteroplasmic skin fibroblast and Epstein-Barr virus-transformed lymphocyte cultures.
The Journal of biological chemistry - 15 Sept 1993
Bourgeron T, Chretien D, Rötig A, Munnich A, Rustin P
Abstract excerpt
We report on the variant phenotypic expression of mitochondrial genotypes in cultured skin fibroblasts and Epstein-Barr virus-transformed lymphocyte cultures from a patient with Pearson syndrome (McKusick no. 260560). Both cell types harbored a heteroplasmic population of normal and deleted mtDNA...
Topics
- Cell Line, Transformed
- Cells, Cultured
- DNA, Mitochondrial
- Electron Transport Complex IV
- Fibroblasts
- Genotype
- Herpesvirus 4, Human
- Lymphocytes
- Mitochondria
- Oxygen Consumption
- Phenotype
- Sequence Deletion
- Skin
- Syndrome
- Transcription, Genetic