Article
The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa.
Nucleic acids research - 1 Jan 2005
Nolan Tony, Braccini Laura, Azzalin Gianluca, De Toni Arianna, Macino Giuseppe, Cogoni Carlo
Abstract excerpt
Post-transcriptional gene silencing (PTGS) involving small interfering RNA (siRNA)-directed degradation of RNA transcripts and transcriptional silencing via DNA methylation have each been proposed as mechanisms of genome defence against invading nucleic acids, such as transposons and viruses. Furthermore, recent data from plants indicates that many transposons are silenced via a combination of the two mechanisms,...
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