Article
MHC class II genes influence the susceptibility to chronic active hepatitis C.
Journal of hepatology - 1 Aug 1997
Höhler T, Gerken G, Notghi A, Knolle P, Lubjuhn R, Taheri H, Schneider P M, Meyer zum Büschenfelde K H, Rittner C
Abstract excerpt
BACKGROUND/AIMS: Chronic hepatitis C develops in more than 70% of hepatitis C virus infected subjects. Viral factors influence the disease course, but little is known about the importance of host factors. METHODS: Frequencies of major histocompatibility complex (MHC) class I and class II antigens...
Topics
- Alleles
- Antilymphocyte Serum
- Disease Progression
- Disease Susceptibility
- Genes, MHC Class II
- Genetic Predisposition to Disease
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DR Antigens
- HLA-DRB1 Chains
- Hepatitis C
- Hepatitis, Chronic
- Histocompatibility Antigens Class I
- Histocompatibility Antigens Class II
- Homozygote
- Humans
- Polymerase Chain Reaction