Article
Sp1-mediated transcriptional activation from the dominant promoter of the rat alpha1B adrenergic receptor gene in DDT1MF-2 cells.
The Journal of biological chemistry - 12 Sept 1997
Chen J, Spector M S, Kunos G, Gao B
Abstract excerpt
In the rat liver, NF1 and CP1 bind to the major P2 promoter of the alpha1B adrenergic receptor gene to generate footprint II. Here we show that, in DDT1MF-2 smooth muscle cells, the major protein bound to footprint II is not NF1 but Sp1, which binds to the 5'-portion of the footprint II sequence...
Topics
- Animals
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cell Nucleus
- DNA Footprinting
- DNA-Binding Proteins
- Gene Expression Regulation
- Liver
- Models, Genetic
- Muscle, Smooth
- Mutation
- NFI Transcription Factors
- Promoter Regions, Genetic
- Protein Binding
- Rats
- Receptors, Adrenergic, alpha-1
- Sp1 Transcription Factor
- Tissue Distribution