Article
MHC-derived peptides and the CD4+ T-cell repertoire: implications for autoimmune disease.
Cytokines, cellular & molecular therapy - 1 Jun 1997
Baum H, Staines N A
Abstract excerpt
The receptor repertoire of peripheral CD4+ cells is primarily determined by selection processes in the thymus. These result in the positive selection of T cells whose receptors weakly recognize self-peptides restricted by class II self-MHC heterodimers. A majority of such self-peptide partial ago...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Arthritis, Rheumatoid
- Autoantigens
- Autoimmune Diseases
- B-Lymphocytes
- CD4-Positive T-Lymphocytes
- Chagas Disease
- Diabetes Mellitus, Type 1
- Histocompatibility Antigens
- Humans
- Immunodominant Epitopes
- Leprosy
- Liver Cirrhosis, Biliary
- Major Histocompatibility Complex
- Models, Biological
- Molecular Mimicry