Article
MHC-derived peptides and the CD4+ T-cell repertoire: implications for autoimmune disease.
Cytokines, cellular & molecular therapy - 1 Jun 1997
Baum H, Staines N A
Abstract excerpt
The receptor repertoire of peripheral CD4+ cells is primarily determined by selection processes in the thymus. These result in the positive selection of T cells whose receptors weakly recognize self-peptides restricted by class II self-MHC heterodimers. A majority of such self-peptide partial agonists are likely to be derived from self-MHC molecules. It is suggested that these thymically selected, weakly...
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