Article
Analysis of suppressor mutation reveals long distance interactions in the bc(1) complex of Saccharomyces cerevisiae.
Biochimica et biophysica acta - 17 Aug 2001
Brasseur G, Di Rago J P, Slonimski P P, Lemesle-Meunier D
Abstract excerpt
Four totally conserved glycines are involved in the packing of the two cytochrome b hemes, b(L) and b(H), of the bc(1) complex. The conserved glycine 131 is involved in the packing of heme b(L) and is separated by only 3 A from this heme in the bc(1) complex structure. The cytochrome b respiratory deficient mutant G131S is affected in the assembly of the bc(1) complex. An intragenic suppressor mutation was...
Topics
- Binding Sites
- Catalysis
- Cytochrome b Group
- Cytochromes c1
- Electron Spin Resonance Spectroscopy
- Electron Transport Complex III
- Models, Molecular
- Mutation
- Oxidation-Reduction
- Oxidoreductases
- Potentiometry
- Saccharomyces cerevisiae
- Spectrophotometry
- Suppression, Genetic