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Article

Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes.

The American journal of physiology - 1 Aug 1997

Alpini G, Glaser S, Robertson W, Phinizy J L, Rodgers R E, Caligiuri A, LeSage G

Abstract excerpt

Accumulation of bile acids (BA) and cholangiocyte proliferation occur in cholestasis, but BA effects on the proliferative and secretory capacity of cholangiocytes are undefined. Cholangiocyte proliferation coupled with increased expression of H3 histone and secretin receptor (SR) genes and secretin-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) levels is limited to large cholangiocytes. We isolated pooled...

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Identifiers

PMID: 9277433
DOI: 10.1152/ajpgi.1997.273.2.G518

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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