Article
CFTR expression but not Cl- transport is involved in the stimulatory effect of bile acids on apical Cl-/HCO3- exchange activity in human pancreatic duct cells.
Pancreas - 1 Nov 2009
Ignáth Imre, Hegyi Péter, Venglovecz Viktória, Székely Csilla A, Carr Georgina, Hasegawa Mamoru, Inoue Makoto, Takács Tamás, Argent Barry E, Gray Michael A, Rakonczay Zoltán
Abstract excerpt
OBJECTIVES: Low doses of chenodeoxycholate (CDC) stimulate apical anion exchange and HCO3(-) secretion in guinea pig pancreatic duct cells (Gut. 2008;57:1102-1112). We examined the effects of CDC on intracellular pH (pHi), intracellular Ca(2+) concentration ([Ca(2+)]i), and apical Cl(-)/HCO3(-) exchange activity in human pancreatic duct cells and determined whether any effects were dependent on cystic fibrosis...
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