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Article

FMR1 premutation allele (CGG)81 is stable in mice.

European journal of human genetics : EJHG - 1 Jan 2000

Bontekoe C J, de Graaff E, Nieuwenhuizen I M, Willemsen R, Oostra B A

Abstract excerpt

Fragile X syndrome is caused by an expansion of the CGG repeat present in the 5' UTR of the FMR1 gene. A lot has been elucidated about the genetics of the disease, but not much is known about the mechanisms involved in repeat instability. Transgenic animals with a premutation allele [(CGG)11AGG(CGG)60CAG(CGG)8] in the human FMR1 promoter were generated to study the inheritance of this repeat in mice. Three...

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Source

Identifiers

PMID: 9412786

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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FMR1 premutation allele (CGG)81 is stable in mice.PMID 9412786Read ↗

Instability of a (CGG)98 repeat in the Fmr1 promoter.Semantic proximity Read ↗

Long uninterrupted CGG repeats within the first exon of the human FMR1 gene are not intrinsically unstable in transgenic mice.Semantic proximity Read ↗

Genetic variation and intergenerational FMR1 CGG-repeat stability in 100 unrelated three-generation families from the normal population.Semantic proximity Read ↗

Mechanisms of the FMR1 Repeat Instability: How Does the CGG Sequence Expand?Semantic proximity Read ↗

ATR protects the genome against CGG.CCG-repeat expansion in Fragile X premutation mice.Semantic proximity Read ↗

Instability of the CGG repeat and expression of the FMR1 protein in a male fragile X patient with a lung tumor.Semantic proximity Read ↗

Frequency and stability of the fragile X premutation.Semantic proximity Read ↗

Trinucleotide repeats (CGG)22TGG(CGG)43TGG(CGG)21 from the fragile X gene remain stable in transgenic mice.Semantic proximity Read ↗

CGG repeat in the FMR1 gene: size matters.Semantic proximity Read ↗

Length of uninterrupted CGG repeats determines instability in the FMR1 gene.Semantic proximity Read ↗

Mouse models of triplet repeat diseases.Semantic proximity Read ↗

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