Article
Structure and diversity of the heavy chain VDJ junctions in the developing Mexican axolotl.
Immunogenetics - 1 Jan 1997
Golub R, Fellah J S, Charlemagne J
Abstract excerpt
The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical structure of all known vertebrate JHs, including the conserved Trp103-Gly104-X-Gly106 motif. Four...
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