Structure and diversity of the heavy chain VDJ junctions in the developing Mexican axolotl.

doi:10.1007/s002510050294

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Article

Structure and diversity of the heavy chain VDJ junctions in the developing Mexican axolotl.

Immunogenetics - 1 Jan 1997

Golub R, Fellah J S, Charlemagne J

Abstract excerpt

The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified...

Topics

Ambystoma
Animals
Gene Rearrangement
Genetic Variation
Immunoglobulin Heavy Chains
Immunoglobulin Joining Region
Immunoglobulin Variable Region
Immunoglobulin mu-Chains
Immunoglobulins
Species Specificity

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