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Article

[Abnormality of p15(INK4b) gene and myelodysplastic syndrome].

Zhongguo shi yan xue ye xue za zhi - 1 Aug 2002

Wang Zhen, Li Yang-Qiu

Abstract excerpt

Among tumor suppressor genes, p15(INK4b) gene is gaining more attention for its important role in the progression of myelodyplastic syndrome (MDS). Serial studies demonstrated that highly frequent hypermethylation of p15(INK4b) gene, which is located at the 5'CpG island in the promoter region of exon 1 and is the main reason of inactivation of p15(INK4b) gene, occurs during the development of MDS towards AML. The...

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PMID: 12513775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Abnormality of p15(INK4b) gene and myelodysplastic syndrome].PMID 12513775Read ↗

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Promoter hypermethylation of <i>p15</i><sup><i>INK</i>4<i>B</i></sup>, <i>HIC1</i>, <i>CDH1</i>, and <i>ER</i> is frequent in myelodysplastic syndrome and predicts poor prognosis in early‐stage patientsSemantic proximity Read ↗

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