Article
Positive association between the GABRA5 gene and unipolar recurrent major depression.
Neuropsychobiology - 1 Jan 1997
Oruc L, Verheyen G R, Furac I, Ivezić S, Jakovljević M, Raeymaekers P, Van Broeckhoven C
Abstract excerpt
The gamma-aminobutyric acid (GABA) neurotransmitter system has been implicated in the pathogenesis of mood disorders. To test this hypothesis we carried out an association study between a dinucleotide repeat polymorphism in the GABAA receptor alpha 5 subunit gene and bipolar and unipolar mood disorders. Our results suggest a possible involvement of this gene in unipolar but not in bipolar disorder.
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