Article
Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1992
Yeger H, Cullinane C, Flenniken A, Chilton-MacNeil S, Campbell C, Huang A, Bonetta L, Coppes M J, Thorner P, Williams B R
Abstract excerpt
The cloning and molecular characterization of two putative tumor genes, WT1 and WIT1, from the chromosome 11p13 region has provided a means of evaluating their role in the generation of Wilms' tumor heterogeneity. A series of 29 tumors were analyzed for WT1 and WIT1 expression by Northern blot or RNase protection analyses, and results were compared with tumor histopathology. Tumors were scored for the percentage...
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