Article
Coordinate expression of Wilms' tumor genes correlates with Wilms' tumor phenotypes.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1992
Yeger H, Cullinane C, Flenniken A, Chilton-MacNeil S, Campbell C, Huang A, Bonetta L, Coppes M J, Thorner P, Williams B R
Abstract excerpt
The cloning and molecular characterization of two putative tumor genes, WT1 and WIT1, from the chromosome 11p13 region has provided a means of evaluating their role in the generation of Wilms' tumor heterogeneity. A series of 29 tumors were analyzed for WT1 and WIT1 expression by Northern blot or...
Topics
- Blotting, Northern
- Cell Differentiation
- Gene Expression Regulation, Neoplastic
- Genes, Wilms Tumor
- Humans
- In Situ Hybridization
- Kidney Neoplasms
- Phenotype
- Wilms Tumor
