Phenytoin kinetics in Japanese adult epileptics: phenotype of phenytoin slow metabolizers.

doi:10.1097/00002826-199708000-00006

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Article

Phenytoin kinetics in Japanese adult epileptics: phenotype of phenytoin slow metabolizers.

Clinical neuropharmacology - 1 Aug 1997

Watanabe M, Iwahashi K, Kugoh T, Suwaki H

Abstract excerpt

Phenytoin pharmacokinetics in 18 of 126 Japanese epileptic patients were investigated using the Michaelis-Menten equation. Five of these (4% of total) patients, who showed significantly high plasma concentrations of phenytoin even when administered a relatively low daily dose of phenytoin, were c...

Topics

Adolescent
Adult
Anticonvulsants
Dose-Response Relationship, Drug
Epilepsy
Female
Humans
Japan
Male
Phenotype
Phenytoin

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