Article
Interaction of thiostrepton with an RNA fragment derived from the plastid-encoded ribosomal RNA of the malaria parasite.
RNA (New York, N.Y.) - 1 Aug 1997
Rogers M J, Bukhman Y V, McCutchan T F, Draper D E
Abstract excerpt
Although eukaryotes are not generally sensitive to thiostrepton, growth of the human malaria parasite Plasmodium falciparum is severely inhibited by the drug. The proposed target in P. falciparum is the ribosome of the plastid-like organelle (35 kb circular genome) of unknown function. Positive i...
Topics
- Animals
- Base Sequence
- Binding Sites
- Magnesium
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Plasmodium falciparum
- Plastids
- Quaternary Ammonium Compounds
- RNA, Protozoan
- RNA, Ribosomal, 23S
- Sodium
- Substrate Specificity
- Thiostrepton