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The possible use of HLA-G1 and G3 in the inhibition of NK cell-mediated swine endothelial cell lysis

1 Oct 2001

Abstract excerpt

The splicing isoform of HLA-G that is expressed in xenogeneic cells, and its effect on NK-mediated direct cytotoxicity was examined, using stable Chinese hamster ovary (CHO) cell or swine endothelial cell (SEC) transfectants. cDNAs of HLA-G (G1 and G3) and human beta2-microglobulin were prepared and subcloned into the expression vector, pCXN. The transfected HLA-G1 was easily expressed on SEC, and co-transfection...

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PMID: 11678914
DOI: 10.1046/j.1365-2249.2001.01622.x

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