Article
Mutation spectrum in the lacI gene, induced by gamma-radiation in aqueous solution under oxic conditions.
Mutation research - 17 Jul 1998
Wijker C A, Wientjes N M, Lafleur V M
Abstract excerpt
Irradiation of DNA in a cellular environment leads to many types of DNA damage, resulting from various effects of gamma-radiation. One of these effects is the formation of water-derived radicals (e.g., .OH radicals), which are formed in the vicinity of DNA (indirect effect). To study the influence of the indirect effect on gamma-radiation-induced mutations, a newly constructed plasmid, containing the lacI gene as...
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