Article
A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci.
Biological psychiatry - 15 Aug 2006
Fyer Abby J, Hamilton Steven P, Durner Martina, Haghighi Fatemeh, Heiman Gary A, Costa Ramiro, Evgrafov Oleg, Adams Philip, de Leon Ada Baisre, Taveras Nilda, Klein Donald F, Hodge Susan E, Weissman Myrna M, Knowles James A
Abstract excerpt
BACKGROUND: Panic disorder (PD) is a common illness with a definite but "complex" genetic contribution and estimated heritability of 30-46%. METHODS: We report a genome scan in 120 multiplex PD pedigrees consisting of 1591 individuals of whom 992 were genotyped with 371 markers at an average spacing of 9cM. Parametric two-point, multipoint, and nonparametric analyses were performed using three PD models (Broad,...
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